Protective Effects of Met-enkephalin on Alcohol Induced Gastric LesionsReport as inadecuate

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Croatica Chemica Acta, Vol.73 No.4 December 2000. -

The model of ethanol induced gastric lesions is useful in the evaluation of gastric cytoprotection. We used it to measure cytoprotective effects of two neuropeptides, Met-enkephalin Peptid-M, LUPEX® and α-melanocyte stimulating hormone α-MSH. Both peptides exhibited significant and synergistic cytoprotective effects. The best therapeutic efficacy was obtained with Met-enkephalin and α-MSH mixture 3-5 : 1. Significant cytoprotective action on ethanol induced lesions was also observed by means of two thymus peptide immunomodulators, Thymus Peptide C® and JAN 50®. Thymus Peptide C® exhibited a more significant synergistic effect with Met-enkephalin than JAN 50®. In addition to the cytoprotection of rat gastric mucosa, Met-enkephalin also induced statistically significant and dose dependent Straub tail response versus control in miče. Haloperidol, naloxone and Peptide-D antagonised its effects. NMR spectrospic data supported molecular interaction of Met-enkephalin and haloperidol, while neutralization of Met-enkephalin induced Straub tail response by means of Peptide-D indicated the presence of new non-opioid naloxone independent receptor system containing Peptide-D sequence calpastatin 201-205 aa.

Met-enkephalin; LUPEX®; α -MSH; ethanol; gastric lesions; peptide-D; cytoprotection; Straub phenomenon; haloperidol; NMR; Thymus Peptide C®; JAN 50®

Author: Paško Konjevoda - ; Department of Pharmacology, Zagreb University School of Medicine, Salata 2, 10000 Zagreb, Croatia Nikola Št



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