Effects of Aging on Genioglossus Motor Units in HumansReportar como inadecuado

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The genioglossus is a major upper airway dilator muscle thought to be important in obstructive sleep apnea pathogenesis. Aging is a risk factor for obstructive sleep apnea although the mechanisms are unclear and the effects of aging on motor unit remodeled in the genioglossus remains unknown. To assess possible changes associated with aging we compared quantitative parameters related to motor unit potential morphology derived from EMG signals in a sample of older n = 11; >55 years versus younger n = 29; <55 years adults. All data were recorded during quiet breathing with the subjects awake. Diagnostic sleep studies Apnea Hypopnea Index confirmed the presence or absence of obstructive sleep apnea. Genioglossus EMG signals were analyzed offline by automated software DQEMG, which estimated a MUP template from each extracted motor unit potential train MUPT for both the selective concentric needle and concentric needle macro CNMACRO recorded EMG signals. 2074 MUPTs from 40 subjects mean±95% CI; older AHI 19.6±9.9 events-hr versus younger AHI 30.1±6.1 events-hr were extracted. MUPs detected in older adults were 32% longer in duration 14.7±0.5 ms versus 11.1±0.2 ms; P  =  0.05, with similar amplitudes 395.2±25.1 µV versus 394.6±13.7 µV. Amplitudes of CNMACRO MUPs detected in older adults were larger by 22% 62.7±6.5 µV versus 51.3±3.0 µV; P<0.05, with areas 24% larger 160.6±18.6 µV.ms versus 130.0±7.4 µV.ms; P<0.05 than those detected in younger adults. These results confirm that remodeled motor units are present in the genioglossus muscle of individuals above 55 years, which may have implications for OSA pathogenesis and aging related upper airway collapsibility.

Autor: Julian P. Saboisky , Daniel W. Stashuk, Andrew Hamilton-Wright, John Trinder, Sanjeev Nandedkar, Atul Malhotra

Fuente: http://plos.srce.hr/


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