Association of UGT1A1 Variants and Hyperbilirubinemia in Breast-Fed Full-Term Chinese InfantsReport as inadecuate

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A retrospective case control study of breast-fed full-term infants was carried out to determine whether variants in Uridine Diphosphate Glucuronosyl Transferase 1A1 UGT1A1 and Heme Oxygenase-1 HMOX1 were associated with neonatal hyperbilirubinemia. Eight genetic variants of UGT1A1 and 3 genetic variants of HMOX1 were genotyped in 170 hyperbilirubinemic newborns and 779 controls. Five significant associations with breast-fed hyperbilirubinemia were detected after adjusting for gender, birth season, birth weight, delivery mode, gestational age and False Discovery Rate FDR correction: the dominant effect of rs887829 c-364t Odds Ratio OR: 0.55; 95% Confidence Interval CI: 0.34–0.89; p = 0.014, the additive effect of TAn repeat OR: 0.59; 95%CI: 0.38–0.91; p = 0.017, the dominant effect of rs4148323 Gly71Arg, G211A OR: 2.02; 95%CI: 1.44–2.85; p = 5.0×10−5, the recessive effect of rs6717546 g+914a OR: 0.30; 95%CI: 0.11–0.83; p = 0.021 and rs6719561 t+2558c OR: 0.38; 95%CI: 0.20–0.75; p = 0.005. Neonates carrying the minor allele of rs887829 TAn repeat had significantly lower peak bilirubin than wild types, while the minor allele carriers of rs4148323 had significantly higher peak bilirubin than wild types. No association was found in HMOX1. Our findings added to the understanding of the significance of UGT1A1 in association with neonatal hyperbilirubinemia in East Asian population. Additional studies were required to investigate the mechanisms of the protective effects.

Author: Youyou Zhou, San-nan Wang, Hong Li, Weifeng Zha, Xuli Wang, Yuanyuan Liu, Jian Sun, Qianqian Peng, Shilin Li, Ying Chen, Li Jin



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