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Croatian medical journal, Vol.55 No.5 October 2014. -

Aim To evaluate the effects of bosentan, sildenafil, and

combined therapy on the cardiovascular system using impedance

cardiography ICG in rats with monocrotaline

MCT-induced pulmonary arterial hypertension PAH.

Methods Seventy male Wistar-albino rats were randomized

into five groups. A single dose of MCT was given to all

rats, except to the control group. After 4 weeks, bosentan,

sildenafil, and combined treatment was started and lasted

for 3 weeks. The last group that developed PAH did not receive

any medication. Echocardiographic evaluation was

performed to determine the PAH development. Thoracic

fluid content index TFCI, stroke volume index SI, heart

rate HR, cardiac index CI, and myocardial contractility index

IC were determined. All procedures were performed

at the baseline and after 4 and 7 weeks.

Results Echocardiographic parameters showed that the

all MCT-injected rats developed PAH. There were no significant

inter- and intra-group differences in TFCI, SI, and

IC P > 0.05, but at the 7th week, CI value in the sildenafil-

treated PAH rats was significantly higher than in other

groups and HR of PAH rats with combined therapy was significantly

lower than in other groups.

Conclusion PAH did not have an effect on LV function of

rats, or if it did, the effect was compensated by physiological

processes. Also, sildenafil treatment deteriorated the LV

cardiac index.



Autor: Belgin Buyukakilli - ; Department of Biophysics, Faculty of Medicine, Mersin University Mersin, Turkey Serkan Gurgul - ; Departme

Fuente: http://hrcak.srce.hr/



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