A computational model of cerebrospinal fluid production and reabsorption driven by Starling forcesReportar como inadecuado

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Croatian medical journal, Vol.55 No.5 October 2014. -

Experimental evidence has cast doubt on the classical

model of river-like cerebrospinal fluid CSF flow from the

choroid plexus to the arachnoid granulations. We propose

a novel model of water transport through the parenchyma

from the microcirculation as driven by Starling forces. This

model investigates the effect of osmotic pressure on water

transport between the cerebral vasculature, the extracellular

space ECS, the perivascular space PVS, and the

CSF. A rigorous literature search was conducted focusing

on experiments which alter the osmolarity of blood or ventricles

and measure the rate of CSF production. Investigations

into the effect of osmotic pressure on the volume of

ventricles and the flux of ions in the blood, choroid plexus

epithelium, and CSF are reviewed. Increasing the osmolarity

of the serum via a bolus injection completely inhibits

nascent fluid flow production in the ventricles. A continuous

injection of a hyperosmolar solution into the ventricles

can increase the volume of the ventricle by up to 125%.

CSF production is altered by 0.231 μL per mOsm in the

ventricle and by 0.835 μL per mOsm in the serum. Water

flux from the ECS to the CSF is identified as a key feature

of intracranial dynamics. A complete mathematical model

with all equations and scenarios is fully described, as well

as a guide to constructing a computational model of intracranial

water balance dynamics. The model proposed in

this article predicts the effects the osmolarity of ECS, blood,

and CSF on water flux in the brain, establishing a link between

osmotic imbalances and pathological conditions

such as hydrocephalus and edema.

Autor: Joel Buishas - ; UIC Department of Bioengineering University of Illinois at Chicago, Chicago, IL, USA Ian G. Gould - ; UIC Depart

Fuente: http://hrcak.srce.hr/


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