The embryonic bloodcerebrospinal fluid barrier function before the formation of the fetal choroid plexus: role in cerebrospinal fluid formation and homeostasisReportar como inadecuado




The embryonic bloodcerebrospinal fluid barrier function before the formation of the fetal choroid plexus: role in cerebrospinal fluid formation and homeostasis - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Croatian medical journal, Vol.55 No.4 August 2014. -

Cerebrospinal fluid CSF has attracted interest as an active

signaling milieu that regulates brain development,

homeostasis, and course disease. CSF is a nutrient-rich fluid,

which also contains growth factors and signaling molecules

that regulate multiple cell functions in the central

nervous system CNS. CSF constitution is controlled tightly

and constituent concentrations are maintained narrow,

depending on developmental stage. From fetal stages to

adult life, CSF is produced mainly by the choroid plexus.

The development and functional activities of the choroid

plexus, and other blood-brain barrier systems in adults,

have been extensively analyzed. However, the study of CSF

production and homeostasis in embryos from the closure

of the anterior neuropore, when the brain cavities become

physiologically sealed, to the formation of the functional

fetal choroid plexus has been largely neglected. This developmental

stage is characterized by tightly controlled morphological

and cellular events in the anterior part of the

CNS, such as rapid brain anlagen growth and initiation of

primary neurogenesis in the neural progenitor cells lining

the cavities, events which are driven by specific molecules

contained within the embryonic CSF. In this article, we review

the existing literature on formation and function of

the temporary embryonic blood-CSF barrier, from closure

of the anterior neuropore to the formation of functional

fetal choroid plexuses, with regard to crucial roles that embryonic

CSF plays in neural development.



Autor: David Bueno - ; Department of Genetics, Faculty of Biology, University of Barcelona, Barcelona, Catalonia, Spain Maryam Parvas -

Fuente: http://hrcak.srce.hr/



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