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International Journal of Alzheimer-s DiseaseVolume 2011 2011, Article ID 239453, 5 pages

Research ArticleStructural Genomics Section, Saha Institute of Nuclear Physics, 1-AF Bidhan Nagar, WB, Kolkata 700 064, India

Received 2 July 2010; Accepted 26 July 2010

Academic Editor: Christiane Reitz

Copyright © 2011 Mithu Raychaudhuri and Debashis Mukhopadhyay. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Amyloid precursor protein APP, implicated in Alzheimer-s disease, is a transmembrane protein of undetermined function. APP is cleaved by gamma-secretase that releases the APP intracellular domain AICD in the cytoplasm. In vitro and in vivo studies have implicated the role of AICD in cell signaling and transcriptional regulation of Gsk3 , KAI1, BACE1, EGFR, and other proteins. In this study, by overexpressing AICD in mouse neuroblastoma cell lines, we have demonstrated the alteration in the expressions of two proteins, patched homolog 1 PTCH1, a receptor for sonic hedgehog signaling, and transient receptor potential cation channel subfamily C member 5 TRPC5, a component of receptor-activated nonselective calcium permeant cation channel. Our results indicate the possibility of regulation by AICD in developmental processes as well as in the maintenance of calcium homeostasis at the transcription level.

Autor: Mithu Raychaudhuri and Debashis Mukhopadhyay



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