Diabetes Mellitus as a Risk Factor for Open-Angle Glaucoma: A Systematic Review and Meta-AnalysisReportar como inadecuado




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Objective

To determine the association between diabetes mellitus DM and primary open-angle glaucoma POAG.

Methods

This is a systematic review and meta-analysis of case-control and cohort studies. The literature search included two databases PubMed and Embase and the reference lists of the retrieved studies. Separate meta-analyses for case-control studies and cohort studies were conducted using random-effects models, with results reported as adjusted odds ratios ORs and relative risks RRs, respectively.

Results

Thirteen studies—seven case-control studies and six population-based cohort studies—were included in this meta-analysis. The pooled RR of the association between DM and POAG based on the risk estimates of the six cohort studies was 1.40 95% CI, 1.25–1.57. The pooled OR of the association between DM and POAG based on the risk estimates of the seven case-control studies was 1.49 95% CI, 1.17–1.88. There was considerable heterogeneity among the case-control studies that reported an association between DM mellitus and POAG P<0.001 and no significant heterogeneity among the cohort studies P = 0.377. After omitting the case-control study that contributed significantly to the heterogeneity, the pooled OR for the association between DM and POAG was 1.35 95% CI, 1.06–1.74.

Conclusions

Individuals with DM have an increased risk of developing POAG.



Autor: Minwen Zhou, Wei Wang, Wenbin Huang, Xiulan Zhang

Fuente: http://plos.srce.hr/



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