Sleep Disturbances and Health-Related Quality of Life in Adults with Steady-State BronchiectasisReportar como inadecuado

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Sleep disturbances are common in patients with chronic lung diseases, but little is known about the prevalence in patients with bronchiectasis. A cross sectional study was conducted to investigate the prevalence and determinants associated with sleep disturbances, and the correlation between sleep disturbances and quality of life QoL in adults with steady-state bronchiectasis.


One hundred and forty-four bronchiectasis patients and eighty healthy subjects were enrolled. Sleep disturbances, daytime sleepiness, and QoL were measured by utilizing the Pittsburgh Sleep Quality Index PSQI, Epworth Sleepiness Scale ESS and St. George Respiratory Questionnaire SGRQ, respectively. Demographic, clinical indices, radiology, spirometry, bacteriology, anxiety and depression were also assessed.


Adults with steady-state bronchiectasis had a higher prevalence of sleep disturbances PSQI>5 57% vs. 29%, P<0.001, but not daytime sleepiness ESS≥10 32% vs. 30%, P = 0.76, compared with healthy subjects. In the multivariate model, determinants associated with sleep disturbances in bronchiectasis patients included depression OR, 10.09; 95% CI, 3.46–29.37; P<0.001, nocturnal cough OR, 1.89; 95% CI, 1.13–3.18; P = 0.016, aging OR, 1.04; 95% CI, 1.01–1.07; P = 0.009 and increased 24-hour sputum volume OR, 2.01; 95% CI, 1.22–3.33; P = 0.006. Patients with sleep disturbances had more significantly impaired QoL affecting all domains than those without. Only 6.2% of patients reported using a sleep medication at least weekly.


In adults with steady-state bronchiectasis, sleep disturbances are more common than in healthy subjects and are related to poorer QoL. Determinants associated with sleep disturbances include depression, aging, nighttime cough and increased sputum volume. Assessment and intervention of sleep disturbances are warranted and may improve QoL.

Autor: Yonghua Gao , Weijie Guan , Gang Xu , Zhiya Lin, Yan Tang, Zhimin Lin, Huimin Li, Yang Gao, Qun Luo, Nanshan Zhong, Rongchang Che



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