Memory Concerns, Memory Performance and Risk of Dementia in Patients with Mild Cognitive ImpairmentReportar como inadecuado

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Concerns about worsening memory -memory concerns-; MC and impairment in memory performance are both predictors of Alzheimer-s dementia AD. The relationship of both in dementia prediction at the pre-dementia disease stage, however, is not well explored. Refined understanding of the contribution of both MC and memory performance in dementia prediction is crucial for defining at-risk populations. We examined the risk of incident AD by MC and memory performance in patients with mild cognitive impairment MCI.


We analyzed data of 417 MCI patients from a longitudinal multicenter observational study. Patients were classified based on presence n = 305 vs. absence n = 112 of MC. Risk of incident AD was estimated with Cox Proportional-Hazards regression models.


Risk of incident AD was increased by MC HR = 2.55, 95%CI: 1.33–4.89, lower memory performance HR = 0.63, 95%CI: 0.56–0.71 and ApoE4-genotype HR = 1.89, 95%CI: 1.18–3.02. An interaction effect between MC and memory performance was observed. The predictive power of MC was greatest for patients with very mild memory impairment and decreased with increasing memory impairment.


Our data suggest that the power of MC as a predictor of future dementia at the MCI stage varies with the patients- level of cognitive impairment. While MC are predictive at early stage MCI, their predictive value at more advanced stages of MCI is reduced. This suggests that loss of insight related to AD may occur at the late stage of MCI.

Autor: Steffen Wolfsgruber , Michael Wagner, Klaus Schmidtke, Lutz Frölich, Alexander Kurz, Stefanie Schulz, Harald Hampel, Isabella He



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