A Fast Method for DEFB1-44C-G SNP Genotyping in Brazilian Patients with PeriodontitisReportar como inadecuado

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Acta stomatologica Croatica, Vol.48 No.3 September 2014. -

Aim: Defensins are cationic antimicrobial peptides expressed in epithelial cells. Such peptides exhibit antibacterial, antifungal and antiviral properties, and are a component of the innate immune response. It has been suggested that they have a protective role in the oral cavity. This study evaluated the DEFB1 polymorphism in diabetic patients with or without periodontitis in comparison to healthy controls. Material and Methods: We used Hairpin-Shaped Primer HP assay to study the distribution of the -44 C-G SNP rs1800972 in 119 human DNAs obtained from diabetic patients and healthy control patients. Results: The results indicate that there are no differences in

distribution between groups and that in diabetic periodontitis patients the homozygous mutant could be found more frequently. Conclusion: Further studies are necessary in order to investigate the role of DEFB1 polymorphisms in diabetic periodontitis patients and the influence of the peptide in periodontal pathogens.

Defensins; Antimicrobial Cationic Peptides; DEFB1 protein, human; Epithelial Cells; Diabetes Complications; Periodontitis

Autor: Renata Cimões - ; PhD, Federal University of Pernambuco, Recife, Brazil Rafael Rafael Amorim Cavalcanti de Siqueira - ; PhD, Fed

Fuente: http://hrcak.srce.hr/


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