Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosusReportar como inadecuado




Albendazolesulphoxide concentrations in plasma and hydatid cyst and prediction of parasitological and clinical outcomes in patients with liver hydatidosis caused by Echinococcus granulosus - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Croatian medical journal, Vol.55 No.2 April 2014. -

Aim To investigate the relationship between plasma and

cyst concentrations of albendazolesulphoxide ASO and

their effects on parasitological findings and disease recurrence

in patients with liver hydatidosis.

Methods The study was conducted at the University Hospital

for Infectious Diseases -Dr. Fran Mihaljević,- Zagreb,

Croatia, between August 2006 and January 2011. Consecutive

patients N = 48, age 6-77 years were treated with

albendazole 3 × 5 mg-kg-d over 28 days before surgical

cyst removal n = 34 or percutaneous evacuation PAIR

n = 14. Plasma ASO was determined on days 10 and 28 of

treatment and cyst concentrations at surgery-PAIR.

Results Disease recurred in 3 surgically treated patients.

Variability of ASO concentrations was substantial. Plasma

concentrations on day 10 were higher than on day

28 geometric means ratio GMR 2.00; 95%CI 1.38-2.91,

P < 0.001 and higher than cyst concentrations at the time

of treatment GMR = 1.58, 1.01-2.34, P = 0.045. Higher cyst

but not plasma concentrations were independently associated

with lower odds of protoscolex motility OR = 0.23,

0.01-0.70, P < 0.001 and higher odds of protoscolex destruction

OR = 1.17, 1.04-1.46, P < 0.001. With adjustment

for age and protoscolex motility, higher day 10 plasma

concentrations but not cyst concentrations were associated

with lower odds of disease recurrence OR = 0.49,

0.09-0.97, P = 0.035. Plasma concentrations did not predict

cyst concentrations.

Conclusion Viability of protoscolices progressively decreased

with increasing ASO concentrations in the cyst.

Data strongly suggested that higher plasma concentrations

reduced the risk of disease recurrence.



Autor: Tomislava Skuhala - ; University Hospital for Infectious Diseases -Fran Mihaljević,- Zagreb,Croatia Vladimir Trkulja - ; Departm

Fuente: http://hrcak.srce.hr/



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