A Nation-Wide Multicenter 10-Year 1999-2008 Retrospective Clinical Study of Endocrine Therapy for Chinese Females with Breast CancerReportar como inadecuado




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Endocrine therapy ET is one of the main systemic treatments for patients with breast cancer. To our knowledge, few studies have addressed the performance of ET or relevant influencing factors in cancer treatment in China. By retrospectively analyzing the clinicopathological data on breast cancer collected from representative hospitals of 7 traditional areas in China in one random month from each year between year 1999 and 2008, we found that: 1 The rate of the use of hormone receptor HR testing was 83.8% 3529-4211, with the estrogen receptor-positive ER+ rate and-or the progesterone receptor-positive PR+ rate being 67.9% 2395-3529, and the ER-PR rate being 32.1% 1134-3529. 2 Of the 1599 patients who had received ET, 999 patients 58.3% were premenopausal while 600 41.7% were postmenopausal; 1598 patients received adjuvant hormonal therapy AHT, whereas only 1 patient received palliative therapy. The medications mainly administered to patients were anti-estrogen agents 80.3% 1283-1598, followed by AIs 15.5% 248-1598. Of the 1598 patients receiving AHT, 1416 patients 88.6% were positive for ER and-or PR, while 75 4.7% were negative for both and 108 patients 6.7% had unknown HR status. The ratio of the use of endocrine therapy for breast cancer patients with ER+ and-or PR+ status was 60.0% 1416-2395. 3 Results from the logistic regression analysis revealed that geography, occupations, and history of chemotherapy and surgery were dependent factors affecting the application of ET in breast cancer treatment in China P<0.001. In conclusion, the use of ET on Chinese women with breast cancer is increasingly and gradually accounted into the standardized process. Economic status, occupations, and history of chemotherapy and surgery were key factors affecting the application of ET. People residing in developed areas, engaging in mental labour, having history of chemotherapy and surgery are susceptible to accept ET.



Autor: Can Zhou , Jian jun He , Jing Li, Jin hu Fan, Bin Zhang, Hong jian Yang, Xiao ming Xie, Zhong hua Tang, Hui Li, Jia yuan Li, Shu

Fuente: http://plos.srce.hr/



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