Epstein-Barr Virus EBV Infection in Chinese Children: A Retrospective Study of Age-Specific PrevalenceReportar como inadecuado




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Background

Epstein-Barr Virus EBV is a globally prevalent herpesvirus associated with infectious mononucleosis and many malignancies. The survey on EBV prevalence appears to be important to study EBV-related diseases and determine when to administer prophylactic vaccine. The purpose of this retrospective study was to collect baseline information about the prevalence of EBV infection in Chinese children.

Methodology-Principal Finding

We collected 1778 serum samples from healthy children aged 0 to 10, who were enrolled in conventional health and nutrition examinations without any EBV-related symptom in 2012 and 2013 in North China n = 973 and South China n = 805. We detected four EBV-specific antibodies, i.e., anti-VCA-IgG and IgM, anti-EBNA-IgG and anti-EA-IgG, by ELISA, representing all of the phases of EBV infection. The overall EBV seroprevalence in samples from North and South China were 80.78% and 79.38% respectively. The EBV seropositivity rates dropped slightly at age 2, and then increased gradually with age. The seroprevalence became stabilized at over 90% after age 8. In this study, the seroprevalence trends between North and South China showed no difference P>0.05, and the trends of average antibody concentrations were similar as well P>0.05.

Conclusions-Significance

EBV seroprevalence became more than 50% before age 3 in Chinese children, and exceed 90% after age 8. This study can be helpful to study the relationship between EBV and EBV-associated diseases, and supportive to EBV vaccine development and implementation.



Autor: Geng Xiong , Bo Zhang , Mu-yun Huang, Hufeng Zhou, Li-zhen Chen, Qi-sheng Feng, Xi Luo, Hui-jia Lin, Yi-xin Zeng

Fuente: http://plos.srce.hr/



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