Von Willebrand Factor Regulation in Patients with Acute and Chronic Cerebrovascular Disease: A Pilot, Case–Control StudyReportar como inadecuado




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Background and Purpose

In animal models, von Willebrand factor VWF is involved in thrombus formation and propagation of ischemic stroke. However, the pathophysiological relevance of this molecule in humans, and its potential use as a biomarker for the risk and severity of ischemic stroke remains unclear. This study had two aims: to identify predictors of altered VWF levels and to examine whether VWF levels differ between acute cerebrovascular events and chronic cerebrovascular disease CCD.

Methods

A case–control study was undertaken between 2010 and 2013 at our University clinic. In total, 116 patients with acute ischemic stroke AIS or transitory ischemic attack TIA, 117 patients with CCD, and 104 healthy volunteers HV were included. Blood was taken at days 0, 1, and 3 in patients with AIS or TIA, and once in CCD patients and HV. VWF serum levels were measured and correlated with demographic and clinical parameters by multivariate linear regression and ANOVA.

Results

Patients with CCD 158±46% had significantly higher VWF levels than HV 113±36%, P<0.001, but lower levels than AIS-TIA patients 200±95%, P<0.001. Age, sex, and stroke severity influenced VWF levels P<0.05.

Conclusions

VWF levels differed across disease subtypes and patient characteristics. Our study confirms increased VWF levels as a risk factor for cerebrovascular disease and, moreover, suggests that it may represent a potential biomarker for stroke severity, warranting further investigation.



Autor: Peter Kraft, Christiane Drechsler, Ignaz Gunreben, Bernhard Nieswandt, Guido Stoll, Peter Ulrich Heuschmann, Christoph Kleinschni

Fuente: http://plos.srce.hr/



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