Association of Circulating C1q-TNF-Related Protein 1 Levels with Coronary Artery Disease in MenReportar como inadecuado

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Obesity is a major risk factor for cardiovascular disease. Recent evidence demonstrates that dysregulation of fat-derived hormones, also known as adipokines, is linked with the pathogenesis of obesity-related disorders including coronary artery disease CAD. Here, we investigated whether circulating level of an adipokine C1q-TNF-related protein CTRP 1 is associated with the prevalence of CAD.

Methods and Results

Consecutive 76 male CAD patients were enrolled from inpatients that underwent coronary angiography. Sixty four healthy male subjects served as controls. Plasma CTRP1 concentration was determined by enzyme-linked immunosorbent assay. CTRP1 levels were correlated positively with systolic blood pressure BP and triglyceride levels, and negatively with HDL cholesterol levels in all subjects. Plasma levels of CTRP1 were significantly higher in CAD patients than in control subjects CAD: 443.3±18.6 ng-ml, control: 307.8±21.5 ng-ml, p<0.001. Multiple logistic regression analysis with body mass index, systolic BP, glucose, total cholesterol, HDL cholesterol, triglyceride, adiponectin and CTRP1 revealed that CTRP1 levels, together with systolic BP and HDL cholesterol, correlated with CAD.


Our data indicate the close association of high CTRP1 levels with CAD prevalence, suggesting that CTRP1 represents a novel biomarker for CAD.

Autor: Daisuke Yuasa, Koji Ohashi , Rei Shibata, Kyosuke Takeshita, Ryosuke Kikuchi, Ryotaro Takahashi, Yoshiyuki Kataoka, Megumi Miyabe



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