Metastatic Squamous Cell Carcinoma Component from an Adenosquamous Carcinoma of the Lung with Identical Epidermal Growth Factor Receptor MutationsReportar como inadecuado




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Case Reports in Pulmonology - Volume 2015 2015, Article ID 283875, 4 pages -

Case Report

Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, OH 43210, USA

Department of Pathology, The Ohio State University College of Medicine, Columbus, OH 43210, USA

Department of Radiology, The Ohio State University College of Medicine, Columbus, OH 43210, USA

Received 24 April 2015; Accepted 2 August 2015

Academic Editor: Nobuyuki Koyama

Copyright © 2015 Jarred Burkart et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

The case reported is a young -light- ex-smoker who initially had a localized adenosquamous carcinoma bearing an epidermal growth factor receptor EGFR sensitizing mutation. He first recurred six months after initial treatment within the brain with a pure squamous histology and the same EGFR mutation. Surgical resection and radiation rendered him disease-free. Subsequent isolated recurrence within the lung eighteen months later was a pure adenocarcinoma, again with the same identified EGFR mutation. These histologic changes from adenosquamous to pure squamous to pure adenocarcinoma have been described but not before in the absence of any selection pressure with EGFR tyrosine kinase inhibitors. This case points out the histologic -flexibility- of EGFR mutant lung cancers and the importance for appropriate molecular testing in nonsmokers with lung cancer of any histologic type.





Autor: Jarred Burkart, Konstantin Shilo, Weiqiang Zhao, Efe Ozkan, Amna Ajam, and Gregory A. Otterson

Fuente: https://www.hindawi.com/



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