Does Chronic Obstructive Pulmonary Disease with or without Type 2 Diabetes Mellitus Influence the Risk of Lung Cancer Result from a Population-Based Cohort StudyReportar como inadecuado




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Background

Previous studies have suggested that chronic obstructive pulmonary disease COPD is an independent risk factor for lung cancer. There are some evidence that people with diabetes are at a risk of developing many forms of cancer, but inconclusive with regard to lung cancer. The aim of this study was to evaluate whether COPD with or without type 2 diabetes mellitus T2DM influences the risk of developing lung cancer.

Methods

This is a retrospective cohort study consisting of 20,730 subjects newly diagnosed with COPD -cases-. Their data was collected from the National Health Insurance system of Taiwan from 1998 to 2010. Among these patients, 5,820 patients had T2DM and 14,910 patients did not have T2DM. The retrospective matched control group consisted of 20,729 subjects without either COPD or T2DM. The control group was matched with the cases for sex, age, and index year the year that the patient was diagnosed with COPD. The subjects were followed until the end of 2011.

Results

The findings of our study showed that the risk of lung cancer was higher in the COPD group than in the non-COPD group, with adjusted hazard ratio HR of 5.02 95% confidence interval CI = 4.23–5.94 among total case group, adjusted HR was 5.38 95% CI = 4.52–6.40 in the cohort without T2DM and adjusted HR was 4.05 95% CI = 3.26–5.03 in the cohort with T2DM. We observed a significantly protective effect from lung cancer adjusted HR = 0.75, 95% CI = 0.63–0.90 of diabetic cohort than non-diabetic cohort among patients with COPD.

Conclusion

Patients with COPD had a significantly higher risk of developing lung cancer than healthy people. However, there was a protective effect of T2DM for lung cancer among patients with COPD. Further investigation may be needed to corroborate the mechanism or bring up reliable reasons.



Autor: Te-Chun Shen, Wei-Sheng Chung, Cheng-Li Lin, Chang-Ching Wei, Chia-Hung Chen, Hung-Jen Chen, Chih-Yen Tu, Te-Chun Hsia, Chuen-Min

Fuente: http://plos.srce.hr/



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