Propofol Inhibits Lipopolysaccharide-Induced Tumor Necrosis Factor-Alpha Expression and Myocardial Depression through Decreasing the Generation of Superoxide Anion in CardiomyocytesReportar como inadecuado




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Oxidative Medicine and Cellular LongevityVolume 2014 2014, Article ID 157376, 12 pages

Research Article

Department of Anesthesiology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China

Department of Orthopedics and Traumatology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China

Department of Anesthesiology, The University of Hongkong Shenzhen Hospital, Shenzhen, Guangdong 518053, China

Received 18 April 2014; Accepted 16 July 2014; Published 11 August 2014

Academic Editor: Neelam Khaper

Copyright © 2014 Jing Tang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

TNF-α has been shown to be a major factor responsible for myocardial depression in sepsis. The aim of this study was to investigate the effect of an anesthetic, propofol, on TNF-α expression in cardiomyocytes treated with LPS both in vivo and in vitro. In cultured cardiomyocytes, compared with control group, propofol significantly reduced protein expression of gp91phox and phosphorylation of extracellular regulated protein kinases 1-2 ERK1-2 and p38 MAPK, which associates with reduced TNF-α production. In in vivo mice studies, propofol significantly improved myocardial depression and increased survival rate of mice after LPS treatment or during endotoxemia, which associates with reduced myocardial TNF-α production, gp91phox, ERK1-2, and p38 MAPK. It is concluded that propofol abrogates LPS-induced TNF-α production and alleviates cardiac depression through gp91phox-ERK1-2 or p38 MAPK signal pathway. These findings have great clinical importance in the application of propofol for patients enduring sepsis.





Autor: Jing Tang, Ji-Jie Hu, Chun-Hua Lu, Jia-Ni Liang, Jin-Fang Xiao, You-Tan Liu, Chun-Shui Lin, and Zai-Sheng Qin

Fuente: https://www.hindawi.com/



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