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BioMed Research International - Volume 2015 2015, Article ID 157360, 9 pages -

Research Article

Department of Surgical Sciences, CIR Dental School, University of Turin, Via Nizza 230, 10126 Turin, Italy

CNR-IMAMOTER, Strada delle Cacce 73, 10135 Turin, Italy

CNR-IMAMOTER Headquarters, Via Canal Bianco 28, 44124 Ferrara, Italy

Department of Veterinary Sciences, University of Turin, Largo Paolo Braccini 2, 10095 Grugliasco, Torino, Italy

Department of Medicine, University of Turin, Via Santena 7, 10126 Turin, Italy

Received 25 July 2014; Revised 29 September 2014; Accepted 15 October 2014

Academic Editor: Seong-Hun Kim

Copyright © 2015 Gianmario Schierano et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ceramic materials are widely used for biomedical applications because of their remarkable biological and mechanical properties. Composites made of alumina and zirconia are particularly interesting owing to their higher toughness with respect to the monolithic materials. On this basis, the present study is focused on the in vivo behavior of alumina toughened zirconia ATZ dental implants treated with a hydrothermal process. A minipig model was implemented to assess the bone healing through histology and mRNA expression at different time points 8, 14, 28, and 56 days. The novel ATZ implant was compared to a titanium clinical standard. The implants were analyzed in terms of microstructure and surface roughness before in vivo tests. The most interesting result deals with a statistically significant higher digital histology index for ATZ implants with respect to titanium standard at 56 days, which is an unprecedented finding, to the authors’ knowledge. Even if further investigations are needed before proposing the clinical use in humans, the tested material proved to be a promising candidate among the possible ceramic dental implants.

Autor: Gianmario Schierano, Federico Mussano, Maria Giulia Faga, Giulio Menicucci, Carlo Manzella, Cristian Sabione, Tullio Genova,



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