Declining Incidence of Hepatitis C Virus Infection among People Who Inject Drugs in a Canadian Setting, 1996-2012Reportar como inadecuado




Declining Incidence of Hepatitis C Virus Infection among People Who Inject Drugs in a Canadian Setting, 1996-2012 - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

People who inject drugs PWID are at high risk of hepatitis C virus HCV infection. Trends in HCV incidence and associated risk factors among PWID recruited between 1996 and 2012 in Vancouver, Canada were evaluated.

Methods

Data were derived from a long-term cohort of PWID in Vancouver. Trends in HCV incidence were evaluated. Factors associated with time to HCV infection were assessed using Cox proportional hazards regression.

Results

Among 2,589, 82% n = 2,121 were HCV antibody-positive at enrollment. Among 364 HCV antibody-negative participants with recent last 30 days injecting at enrollment, 126 HCV seroconversions were observed Overall HCV incidence density: 8.6 cases-100 person-years py; 95% confidence interval 95% CI: 7.2, 10.1; HCV incidence density among those with injecting during follow-up: 11.5 cases-100 py; 95% CI 9.7, 13.6. The overall HCV incidence density declined significantly from 25.0-100 py 95% CI: 20.2, 30.3 in 1996–99, as compared to 6.0-100 py 95% CI: 4.1, 8.5 in 2000–2005, and 3.1-100 py 95% CI: 2.0, 4.8 in 2006–2012. Among those with injecting during follow-up, the overall HCV incidence density declined significantly from 27.9-100 py 95% CI: 22.6, 33.6 in 1996–99, as compared to 7.5-100 py 95% CI: 5.1, 10.6 in 2000–2005, and 4.9-100 py 95% CI: 3.1, 7.4 in 2006–2012. Unstable housing, HIV infection, and injecting of cocaine, heroin and methamphetamine were independently associated with HCV seroconversion.

Conclusions

HCV incidence has dramatically declined among PWID in this setting. However, improved public health strategies to prevent and treat HCV are urgently required to reduce HCV-associated morbidity and mortality.



Autor: Jason Grebely , Viviane Dias Lima, Brandon D. L. Marshall, M-J Milloy, Kora DeBeck, Julio Montaner, Annick Simo, Mel Krajden, Gre

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados