Intermediate-Type Vancomycin Resistance VISA in Genetically-Distinct Staphylococcus aureus Isolates Is Linked to Specific, Reversible Metabolic AlterationsReportar como inadecuado




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Intermediate VISA-type vancomycin resistance in Staphylococcus aureus has been associated with a range of physiologic and genetic alterations. Previous work described the emergence of VISA-type resistance in two clonally-distinct series of isolates. In both series the first belonging to MRSA clone ST8-USA300, and the second to ST5-USA100, resistance was conferred by a single mutation in yvqF a negative regulator of the vraSR two-component system associated with vancomycin resistance. In the USA300 series, resistance was reversed by a secondary mutation in vraSR. In this study, we combined systems-level metabolomic profiling with statistical modeling techniques to discover specific, reversible metabolic alterations associated with the VISA phenotype.



Autor: Elizabeth L. Alexander , Susana Gardete, Haim Y. Bar, Martin T. Wells, Alexander Tomasz, Kyu Y. Rhee

Fuente: http://plos.srce.hr/



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