Whole-Genome Analysis of a Rare Human Korean G3P9 Rotavirus Strain Suggests a Complex Evolutionary Origin Potentially Involving Reassortment Events between Feline and Bovine RotavirusesReportar como inadecuado




Whole-Genome Analysis of a Rare Human Korean G3P9 Rotavirus Strain Suggests a Complex Evolutionary Origin Potentially Involving Reassortment Events between Feline and Bovine Rotaviruses - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

A rare human rotavirus, G3P9 strain RVA-Human-tc-KOR-CAU12-2-51-2013-G3P9, was isolated from the stool of a 9-year-old female hospitalized with acute watery diarrhea in August 2012 in South Korea using a cell culture system, and its genome was analyzed. The complete genomic constellation of the CAU12-2-51 strain revealed a novel genotype constellation for human rotavirus, G3-P9-I2-R2-C2-M2-A3-N2-T3-E3-H3. Phylogenetic analysis revealed that the CAU12-2-51 strain originated from feline- and bovine-like reassortment strains. The genes encoding VP4, VP7, NSP1, NSP3, NSP4, and NSP5 were related to human-feline-like and feline rotavirus strains, whereas the remaining five genes encoding VP1, VP2, VP3, VP6, and NSP2 were related to the human-bovine-like and bovine rotavirus strains. This novel strain was identified for the first time, providing evidence of feline-bovine-to-human transmission of rotavirus. The data presented herein provide information regarding rotavirus diversity and evolution.



Autor: Sunyoung Jeong, Van Thai Than, Inseok Lim, Wonyong Kim

Fuente: http://plos.srce.hr/



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