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Clinical and Developmental Immunology - Volume 12 2005, Issue 1, Pages 1-9

Department of Human Biology ES 301, University of Wisconsin-Green Bay, 2420 Nicolet Drive, Green Bay 54311, WI, USA

Department of Nutrition, University of California, One Shields Avenue, Davis 95616, CA, USA

Sacramento Medical Foundation, Center for Blood Research, 1625 Stockton Boulevard, Sacramento 95816, CA, USA

Mars Incorporated, 800High Street, Hackettstown 07840, NJ, USA

Department of Internal Medicine, University of California, One Shields Avenue, Davis, CA, USA

Copyright © 2005 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Platelet activity and platelet-endothelial cell interactions are important in the acute development of thrombosis, as well as in the pathogenesis of cardiovascular disease. An increasing number of foods have been reported to have platelet-inhibitory actions, and research with a number of flavanol-rich foods, including, grape juice, cocoa and chocolate, suggests that these foods may provide some protection against thrombosis. In the present report, we review a series of in vivo studies on the effects of flavanol-rich cocoa and chocolate on platelet activation and platelet-dependent primary hemostasis. Consumption of flavanol-rich cocoa inhibited several measures of platelet activity including, epinephrine- and ADP-induced glycoprotein GP IIb-IIIa and P-Selectin expression, platelet microparticle formation, and epinephrine-collagen and ADP-collagen induced primary hemostasis. The epinephrine-induced inhibitory effects on GP IIb-IIIa and primary hemostasis were similar to, though less robust than those associated with the use of low dose 81 mg aspirin. These data, coupled with information from other studies, support the concept that flavanols present in cocoa and chocolate can modulate platelet function through a multitude of pathways.

Autor: Debra A. Pearson, Roberta R. Holt, Dietrich Rein, Teresa Paglieroni, Harold H. Schmitz, and Carl L. Keen

Fuente: https://www.hindawi.com/


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