The Clinical Impact of Cerebellar Grey Matter Pathology in Multiple SclerosisReportar como inadecuado




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Background

The cerebellum is an important site for cortical demyelination in multiple sclerosis, but the functional significance of this finding is not fully understood.

Objective

To evaluate the clinical and cognitive impact of cerebellar grey-matter pathology in multiple sclerosis patients.

Methods

Forty-two relapsing-remitting multiple sclerosis patients and 30 controls underwent clinical assessment including the Multiple Sclerosis Functional Composite, Expanded Disability Status Scale EDSS and cerebellar functional system FS score, and cognitive evaluation, including the Paced Auditory Serial Addition Test PASAT and the Symbol-Digit Modalities Test SDMT. Magnetic resonance imaging was performed with a 3T scanner and variables of interest were: brain white-matter and cortical lesion load, cerebellar intracortical and leukocortical lesion volumes, and brain cortical and cerebellar white-matter and grey-matter volumes.

Results

After multivariate analysis high burden of cerebellar intracortical lesions was the only predictor for the EDSS p<0.001, cerebellar FS p = 0.002, arm function p = 0.049, and for leg function p<0.001. Patients with high burden of cerebellar leukocortical lesions had lower PASAT scores p = 0.013, while patients with greater volumes of cerebellar intracortical lesions had worse SDMT scores p = 0.015.

Conclusions

Cerebellar grey-matter pathology is widely present and contributes to clinical dysfunction in relapsing-remitting multiple sclerosis patients, independently of brain grey-matter damage.



Autor: Alfredo Damasceno , Benito Pereira Damasceno, Fernando Cendes

Fuente: http://plos.srce.hr/



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