The Interaction of Plasma Sialylated and Desialylated Lipoproteins with Collagen from the Intima and Media of Uninvolved and Atherosclerotic Human AortaReportar como inadecuado




The Interaction of Plasma Sialylated and Desialylated Lipoproteins with Collagen from the Intima and Media of Uninvolved and Atherosclerotic Human Aorta - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Journal of LipidsVolume 2011 2011, Article ID 254267, 8 pages

Research Article

Laboratory of Cellular Mechanisms of Atherogenesis, Institute of General Pathology and Pathophysiology, 8 Baltiyskaya Street, 125315 Moscow, Russia

Laboratory of Cellular Mechanisms of Atheroscleroris, Institute of Experimental Cardiology and Laboratory of Medical Genetics, A.N. Myasnikov Institute of Clinical Cardiology, Cardiology Research Center, 15a 3rd Cherepkovskaya Street, 121552 Moscow, Russia

Institute for Atherosclerosis Research, Skolkovo Innovative Center, 121355 Moscow, Russia

Department of Human and Animal Physiology, Faculty of Biology, M.V. Lomonosov Moscow State University, 1-12 Leninskie Gory, 119991 Moscow, Russia

Received 1 June 2011; Accepted 28 September 2011

Academic Editor: Shinichi Oikawa

Copyright © 2011 Igor A. Sobenin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

We have evaluated the binding of sialylated and desialylated lipoproteins to collagen isolated from the proteoglycan and musculoelastic layers of intima and media of uninvolved human aorta and atherosclerotic lesions. Comparing various collagen preparations from the uninvolved intima-media, the binding of sialylated apoB-containing lipoproteins was best to collagen from the intimal PG-rich layer. Binding of sialylated apoB-containing lipoproteins to collagen from this layer of fatty streak and fibroatheroma was 1.4- and 3.1-fold lower, respectively, in comparison with normal intima. Desialylated VLDL versus sialylated one exhibited a greater binding 1.4- to 3.0-fold to all the collagen preparations examined. Desialylated IDL and LDL showed a higher binding than sialylated ones when collagen from the intimal layers of fibroatheroma was used. Binding of desialylated HDL to collagen from the intimal PG-rich layer of normal tissue, initial lesion, and fatty streak was 1.2- to 2.0-fold higher compared with sialylated HDL.





Autor: Igor A. Sobenin, Igor V. Suprun, Vasiliy P. Karagodin, Alexander S. Feoktistov, Alexandra A. Melnichenko, and Alexander N. Or

Fuente: https://www.hindawi.com/



DESCARGAR PDF




Documentos relacionados