Longer Telomere Length in COPD Patients with α1-Antitrypsin Deficiency Independent of Lung FunctionReportar como inadecuado




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Oxidative stress is involved in the pathogenesis of airway obstruction in α1-antitrypsin deficient patients. This may result in a shortening of telomere length, resulting in cellular senescence. To test whether telomere length differs in α1-antitrypsin deficient patients compared with controls, we measured telomere length in DNA from peripheral blood cells of 217 α1-antitrypsin deficient patients and 217 control COPD patients. We also tested for differences in telomere length between DNA from blood and DNA from lung tissue in a subset of 51 controls. We found that telomere length in the blood was significantly longer in α1-antitrypsin deficient COPD patients compared with control COPD patients p = 1×10−29. Telomere length was not related to lung function in α1-antitrypsin deficient patients p = 0.3122 or in COPD controls p = 0.1430. Although mean telomere length was significantly shorter in the blood when compared with the lungs p = 0.0078, telomere length was correlated between the two tissue types p = 0.0122. Our results indicate that telomere length is better preserved in α1-antitrypsin deficient COPD patients than in non-deficient patients. In addition, measurement of telomere length in the blood may be a suitable surrogate for measurement in the lung.



Autor: Aabida Saferali, Jee Lee, Don D. Sin, Farshid N. Rouhani, Mark L. Brantly, Andrew J. Sandford

Fuente: http://plos.srce.hr/



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