Frontal White Matter Alterations in Short-Term Medicated Panic Disorder Patients without Comorbid Conditions: A Diffusion Tensor Imaging StudyReportar como inadecuado




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The frontal cortex might play an important role in the fear network, and white matter WM integrity could be related to the pathophysiology of panic disorder PD. A few studies have investigated alterations of WM integrity in PD. The aim of this study was to determine frontal WM integrity differences between patients with PD without comorbid conditions and healthy control HC subjects by using diffusion tensor imaging. Thirty-six patients with PD who had used medication within 1 week and 27 age- and sex-matched HC subjects participated in this study. Structural brain magnetic resonance imaging was performed on all participants. Panic Disorder Severity Scale and Beck Anxiety Inventory BAI scores were assessed. Tract-based spatial statistics TBSS was used for image analysis. TBSS analysis showed decreased fractional anisotropy FA in frontal WM and WM around the frontal lobe, including the corpus callosum of both hemispheres, in patients with PD compared to HC subjects. Moreover, voxel-wise correlation analysis revealed that the BAI scores for patients with PD were positively correlated with their FA values for regions showing group differences in the FA of frontal WM of both hemispheres. Altered integrity in frontal WM of patients with PD without comorbid conditions might represent the structural pathophysiology in these patients, and these changes could be related to clinical symptoms of PD.



Autor: Borah Kim, Jeong Hoon Kim, Min-Kyoung Kim, Kang Soo Lee, Youngki Kim, Tai Kiu Choi, Yun Tai Kim , Sang-Hyuk Lee

Fuente: http://plos.srce.hr/



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