Long Noncoding RNAs in Digestive System Malignancies: A Novel Class of Cancer Biomarkers and Therapeutic TargetsReportar como inadecuado

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Gastroenterology Research and Practice - Volume 2015 2015, Article ID 319861, 18 pages -

Review ArticleDepartment of Biochemistry and Molecular Biology, University of Athens, 15701 Athens, Greece

Received 23 November 2014; Accepted 20 April 2015

Academic Editor: Roberto César P. Lima-Júnior

Copyright © 2015 Athina Kladi-Skandali et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


High throughput methodologies have revealed the existence of an unexpectedly large number of long noncoding RNAs lncRNAs. The unconventional role of lncRNAs in gene expression regulation and their broad implication in oncogenic and tumor suppressive pathways have introduced lncRNAs as novel biological tumor markers. The most prominent example of lncRNAs application in routine clinical practice is PCA3, a FDA-approved biomarker for prostate cancer. Regarding digestive system malignancies, the oncogenic HOTAIR is one of the most widely studied lncRNAs in the preclinical level and has already been identified as a potent prognostic marker for major malignancies of the gastrointestinal tract. Here, we provide an overview of recent findings regarding the emerging role of lncRNAs not only as key regulators of cancer initiation and progression in colon, stomach, pancreatic, liver, and esophageal cancers, but also as reliable tumor markers and therapeutic tools. lncRNAs can be easily, rapidly, and cost-effectively determined in tissues, serum, and gastric juice, making them highly versatile analytes. Taking also into consideration the largely unmet clinical need for early diagnosis and more accurate prognostic-predictive markers for gastrointestinal cancer patients, we comment upon the perspectives of lncRNAs as efficient molecular tools that could aid in the clinical management.

Autor: Athina Kladi-Skandali, Kleita Michaelidou, Andreas Scorilas, and Konstantinos Mavridis

Fuente: https://www.hindawi.com/


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