Sodium Tanshinone IIA Sulfonate Attenuates Scopolamine-Induced Cognitive Dysfunctions via Improving Cholinergic SystemReportar como inadecuado




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BioMed Research International - Volume 2016 2016, Article ID 9852536, 9 pages -

Research Article

Institute of Clinical Pharmacology, Guangzhou University of Chinese Medicine, Guangzhou 510405, China

The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou University of Chinese Medicine, Guangzhou 510405, China

School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510405, China

Received 25 March 2016; Revised 20 June 2016; Accepted 29 June 2016

Academic Editor: Mahendra P. Singh

Copyright © 2016 Qing-Qing Xu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Sodium Tanshinone IIA sulfonate STS is a derivative of Tanshinone IIA Tan IIA. Tan IIA has been reported to possess neuroprotective effects against Alzheimer’s disease AD. However, whether STS possesses effect on AD remains unclear. This study aims to estimate whether STS could protect against scopolamine- SCOP- induced learning and memory deficit in Kunming mice. Morris water maze results showed that oral administration of STS 10 mg-kg and 20 mg-kg and Donepezil shortened escape latency, increased crossing times of the original position of the platform, and increased the time spent in the target quadrant. STS decreased the activity of acetylcholinesterase AChE and increased the activity of choline acetyltransferase ChAT in the hippocampus and cortex of SCOP-treated mice. Oxidative stress results showed that STS increased the activity of superoxide dismutase SOD and decreased the levels of malondialdehyde MDA and reactive oxygen species ROS in hippocampus and cortex. In addition, western blot was carried out to detect the expression of apoptosis related proteins Bcl-2, Bax, and Caspase-3. STS upregulated the protein expression of Bcl-2 and downregulated the proteins expression of Bax and Caspase-3. These results indicated that STS might become a promising therapeutic candidate for attenuating AD-like pathological dysfunction.





Autor: Qing-Qing Xu, Yi-Jun Xu, Cong Yang, Ying Tang, Lin Li, Hao-Bin Cai, Bo-Nan Hou, Hui-Fang Chen, Qi Wang, Xu-Guang Shi, an

Fuente: https://www.hindawi.com/



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