Various Blood Glucose Parameters that Indicate Hyperglycemia after Intravenous Thrombolysis in Acute Ischemic Stroke Could Predict Worse OutcomeReportar como inadecuado




Various Blood Glucose Parameters that Indicate Hyperglycemia after Intravenous Thrombolysis in Acute Ischemic Stroke Could Predict Worse Outcome - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

Hyperglycemia is common after stroke, and it is well known to worsen its outcome. However, it is important to consider that blood glucose BG levels can undergo dynamic changes during the acute stage of ischemic stroke. We sought to investigate the clinical significance of various glucose parameters within first 24 hours in acute ischemic stroke AIS. The study focused on hyperacute stage patients who underwent IVT and investigated which parameters of glucose demonstrated to be helpful for predicting outcome.

Methods

This was a retrospective study of consecutive patients with AIS at a single stroke center. Patients were consecutively enrolled if they were treated with IV-tPA within 3 hours of symptom onset. BG was measured immediately upon arrival in ER, after IVT and every 6–8 hours during the first 24 hours after IVT. The various parameters of BG were the following: BG before IVT, BG after IVT, mean BG mBG, maximal BG max BG, standard deviation of BG sdBG, and standard deviation of mean BG sdmBG.

Results

207 patients 127 men and 80 women were included in this study. Seventy seven of 207 patients had favorable outcomes at 3 months. High BG after IVT, mBG and max BG were independently associated with mRS>2 at 3 months adjusted by age, NIHSS, and atrial fibrillation. Several parameters of BG were also independently associated with early mortality within 3 months BG after IVT, mBG, and max BG. BG after IVT and mBG over 180 mg-dL were independently associated with early mortality within 3 months.

Conclusion

Serial measurements of BG might be a better predictor of clinical outcome in patients with AIS treated with IVT than single BG measurements before IVT. Therefore, these results suggest that variable parameters of BG could be important for the prediction of clinical outcome in AIS treated with IVT.



Autor: Deok-Sang Yoo, Jane Chang, Joon-Tae Kim , Min-Ji Choi, Jina Choi, Kang-Ho Choi, Man-Seok Park, Ki-Hyun Cho

Fuente: http://plos.srce.hr/



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