Malondialdehyde and 8-oxo-7.8-dihydro-2’Deoxyguanosine in the Urine of Residents from Balkan Endemic Nephropathy Area in Croatia – A Pilot StudyReportar como inadecuado




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Collegium antropologicum, Vol.37 No.4 December 2013. -

Balkan endemic nephropathy BEN is a human chronic tubulointerstitial renal disease that occurs in rural areas of some Balkan countries. The disease is insidious and fatal, and mostly affects persons in their sixties or seventies. BEN areas have unusually high rates of otherwise rare upper urinary tract tumors UTT. Since extensive production of reactive oxygen species leading to oxidative stress has been implicated in tumor development, the aim of this study was to see whether oxidative stress is involved in the development of BEN and UTT. Urine samples were collected from a BEN village N=22 and a control village N=16 residents and analyzed for malondialdehyde MDA and 8-oxo-7,8-dihydro-2’deoxyguanosine 8-oxodG. The levels of both oxidative stress parameters were significantly higher in the BEN village residents than controls. However, there was no correlation between MDA and 8-oxodG results. Our results confirm that oxidative stress could be implicated in development of both, BEN and UTT.

biomarkers of oxidative stress; healthy subjects; kidney; urinary tract tumors



Autor: Ana-Marija Domijan - ; University of Zagreb, Faculty of Pharmacy and Biochemistry, Zagreb, Croatia Marica Miletić-Medved - ; Ins

Fuente: http://hrcak.srce.hr/



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