Kaposis Sarcoma-Associated Herpesvirus KSHV vIL-6 Promotes Cell Proliferation and Migration by Upregulating DNMT1 via STAT3 ActivationReportar como inadecuado




Kaposis Sarcoma-Associated Herpesvirus KSHV vIL-6 Promotes Cell Proliferation and Migration by Upregulating DNMT1 via STAT3 Activation - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Kaposi-s sarcoma-associated herpesvirus KSHV is etiologically associated with Kaposi-s sarcoma KS, the most common AIDS-related malignancy. KSHV vIL-6 promotes KS development, but the exact mechanisms remain unclear. Here, we reported that KSHV vIL-6 enhanced the expression of DNA methyltransferase 1 DNMT1 in endothelial cells,increased the global genomic DNA methylation, and promoted cell proliferation and migration. And this effect could be blocked by the DNA methyltransferase inhibitor, 5-azadeoxycytidine. We also showed that vIL-6 induced up-regulation of DNMT1 was dependent on STAT3 activation. Therefore, the present study suggests that vIL-6 plays a role in KS tumorigenesis partly by activating DNMT1 and inducing aberrant DNA methylation, and it might be a potential target for KS therapy.



Autor: Jing Wu, Yuqiao Xu, Dongping Mo, Peijun Huang, Ruihong Sun, Lei Huang, Shiyang Pan , Jian Xu

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados