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Canadian Journal of Gastroenterology - Volume 2 1988, Issue 3, Pages 127-132

Review MRC Clinical Research Centre, Harrow, Middlesex, UK

Received 26 April 1988; Accepted 27 April 1988

Copyright © 1988 Hindawi Publishing Corporation. This open-access article is distributed under the terms of the Creative Commons Attribution Non-Commercial License CC BY-NC, which permits reuse, distribution and reproduction of the article, provided that the original work is properly cited and the reuse is restricted to noncommercial purposes.


Intestinal permeability has been assessed with three different classesof permeability probes, viz various sugar mixtures,

Cr-EDTA and polyethyleneglycol. The former two methods are having increasing clinical applications in thescreening and assessment of small intestinal damage and

Cr-EDTA is now the preferredprobe for routine clinical use. Polyethylene glycols have numerous disadvantagesand are not recommended. Probes may be used both in vitro and in vivoand have been applied to a wide variety of clinical problems. In particular, NSAID inducedenteropathy, a major complication of the chronic administration of thesewidely-used drugs, was recognized for the first time with

Cr-EDTA permeabilitymeasurements. The cytoprotective role of various prostanoids was also clearly demonstratedusing

Cr-EDTA. It is anticipated that measurement of intestinal permeabilitywill play an increasing role in clinical and research investigation and in themonitoring of intestinal disease.

Autor: Timothy J. Peters and Ingvar Bjarnason



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