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International Journal of EndocrinologyVolume 2012 2012, Article ID 867415, 6 pages

Clinical Study

Clinical Research Center CRC, “Gabriele d-Annunzio” University Foundation, 66013 Chieti, Italy

“Leonardo da Vinci” Online University, Torrevecchia Teatina, 66013 Chieti, Italy

Chair of Metabolic Diseases, Department of Clinical and Surgical Sciences, University of Padua, 35122 Padua, Italy

Section of Endocrinology, Centre for Aging Sciences CESI, “Gabriele d-Annunzio” University Foundation, 66013 Chieti, Italy

Section of Endocrinology, Department of Human Movement Sciences, “Gabriele d-Annunzio” University, 66013 Chieti, Italy

Section of Endocrinology, Department of Medicine and Sciences of Aging, “Gabriele d-Annunzio” University, 66013 Chieti, Italy

Received 13 December 2011; Revised 27 February 2012; Accepted 27 February 2012

Academic Editor: Alexandra Kautzky-Willer

Copyright © 2012 Ester Vitacolonna et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. About 10% of pregnancies are complicated by previously unknown impairment of glucose metabolism, which is defined as gestational diabetes. There are little data available on prevalence of thyroid disorders in patients affected by gestational diabetes, and about their postgestational thyroid function and autoimmunity. We therefore investigated pancreatic and thyroid autoimmunity in gestational diabetic patients and in women who had had a previous gestational diabetic pregnancy. Methods. We investigated 126 pregnant women at the time of a 100-g oral glucose tolerance test: 91 were classified as gestational diabetics, and 35 were negative controls. We also studied 69 women who had delivered a baby 18–120 months prior to this investigation and who were classified at that time gestational diabetics 38 women or normally pregnant 31 women; controls. Results. Our data show no differences for both thyroid function and prevalence of autoimmune disorders during pregnancy; however, a significant increase in thyroid autoimmunity was seen in women previously affected by gestational diabetes. This increased prevalence of thyroid autoimmunity was not associated with the development of impaired glucose metabolism after pregnancy. Conclusions. Our data suggest that maternal hyperglycemia is a risk factor for the development of thyroid autoimmunity, a conclusion that should now be confirmed in a larger cohort of patients.

Autor: Ester Vitacolonna, Annunziata Lapolla, Barbara Di Nenno, Annalisa Passante, Ines Bucci, Cesidio Giuliani, Dominique Cerrone,



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