Pharmacokinetic Study of Di-Phenyl-Di-2,4-DifluobenzohydroxamatoTinIV: Novel Metal-Based Complex with Promising Antitumor PotentialReportar como inadecuado




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Bioinorganic Chemistry and ApplicationsVolume 2012 2012, Article ID 210682, 8 pages

Research ArticleSchool of Pharmaceutical Science, Shanxi Medical University, Taiyuan 030001, China

Received 31 August 2011; Revised 31 October 2011; Accepted 17 November 2011

Academic Editor: Sanja Mijatović

Copyright © 2012 Yunlan Li et al. This is an open access article distributed under the Creative Commons Attribution License,which permits unrestricted use,distribution,and reproduction in any medium,provided the original work is properly cited.

Abstract

Di-phenyl-di-2,4-difluobenzohydroxamatotinIVDPDFT, a new metal-based arylhydroxamate antitumor complex, showed high in vivo and in vitro antitumor activity with relative low toxicity, but no data was reported regarding its pharmacokinetics and dependent toxicity. In this paper, a rapid, sensitive, and reproducible HPLC method in vivo using Diamonsil ODS column with a mixture of methanol and phosphoric acid in water 30 : 70, V-V, pH 3.0 as mobile phase was developed and validated for the determination of DPDFT. The plasma was deproteinized with methanol that contained acetanilide as the internal standard I.S

The photodiode array detector was set at a wavelength of 228 nm at room temperature and a linear curve over the concentration range 0.1~25 μg·mL

r = 0.9993 was obtained. The method was used to determine the concentration-time profiles for DPDFT in the plasma after single intravenous administration with doses of 5, 10, 15 mg·kg

to rats. The pharmacokinetics parameter calculations and modeling were carried out using the 3p97 software. The results showed that the concentration-time curves of DPDFT in rat plasma could be fitted to two-compartment model.





Autor: Yunlan Li, Zhuyan Gao, Pu Guo, and Qingshan Li

Fuente: https://www.hindawi.com/



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