The Association between Adiposity, Mental Well-Being, and Quality of Life in Extreme ObesityReportar como inadecuado

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To explore the cross-sectional association between adiposity, mental well-being, and quality of life in extreme obese individuals entering a UK specialist weight management service prior to treatment commencement.


The sample comprised 263 extreme obese individuals who were referred to the service as a result of having a body mass index BMI ≥40 kg-m2 or ≥35 kg-m2 with a co-morbid health condition. In a retrospective analysis, routinely collected baseline clinical examination data and self-report questionnaires Impact of Weight on Quality of Life: IWQOL-Lite, EQ5D-3L, and Hospital Anxiety and Depression Scale: HADS were analysed to examine the cross-sectional association between adiposity and quality of life.


The sample was predominantly female 74.8% with mean BMI 47.0±7.9 kg-m2. Increasing adiposity was significantly negatively associated with quality of life, with an increase of 1 BMI unit associated with decreases of 1.93 in physical function 95% CI −2.86 − −1.00, p<0.001, 1.62 in self-esteem 95% CI −2.67 − −0.57, p<0.05, 2.69 in public distress 95% CI −3.75 − −1.62, p<0.001, 1.33 in work 95% CI −2.63 − −0.02, p<0.05, and 1.79 in total IWQOL-Lite scores 95% CI −2.65 − −0.93, p<0.001. Adiposity was associated with significantly increased risk of problems in mobility OR = 3.44, 95% CI 1.47−8.05, and performing usual activities OR = 2.45, 95% CI 1.10−5.46 in highest relative to lowest BMI tertile. The prevalence of experience of symptoms of anxiety 70.3% and depression 66.2% as measured by HADS was consistently high.


We identified a high prevalence of psychological co-morbidity, including widespread experience of symptoms of anxiety and depressive disorders and reduced quality of life among these extreme obese individuals seeking weight management treatment. Clinical implications include the need for the incorporation of strategies to improve mental well-being into multi-disciplinary weight management interventions.

Autor: Alison C. Jagielski, Adrian Brown, Marzieh Hosseini-Araghi, G. Neil Thomas , Shahrad Taheri



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