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E-Journal of Chemistry - Volume 4 2007, Issue 3, Pages 294-301



Department of Pharmaceutical Sciences, Dr. Hari Singh Gour University, Sagar 470 003, M.P., India

Institute of Pharmacy, Pt. Ravi Shankar Shukla University, Raipur, Chhattisgarh, India

G.L.A. Institute of Pharmaceutical Research, Mathura, U.P., India

Received 26 November 2006; Accepted 23 December 2006

Copyright © 2007 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ever since Nuclear Magnetic Resonance NMR spectroscopy hit the analytical scene; its capabilities and applications continue to evolve. Originally designed as a way to verify the structure of relatively small compounds, the technology of NMR has exploded and become a valuable means for studying protein structure. NMR has proved to be a valuable tool in pharmaceutical research, as it has entered new arena of drug discovery and structural genomics. NMR can provide information on the three-dimensional structures of small molecules in solution, high-molecular-weight complexes, and the details of enzyme mechanisms that can be used to aid in drug design. In the present scenario, the availability of high magnetic fields; improved software, high resolution probes, and electronics; more versatile pulse programmers; and most importantly the development of 2D, 3D and 4D NMR, have revolutionized the field of drug discovery and development.





Autor: Neeraj Upmanyu, Gopal Garg, Archana Dolly, and Pradeep Mishra

Fuente: https://www.hindawi.com/



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