The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1–5 Chronic Kidney DiseaseReportar como inadecuado




The Association between 25-Hydroxyvitamin D and Hemoglobin A1c Levels in Patients with Type 2 Diabetes and Stage 1–5 Chronic Kidney Disease - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

International Journal of Endocrinology - Volume 2014 2014, Article ID 142468, 6 pages -

Research Article

Department of Endocrinology and Nutrition, University Hospital of Amiens, 80054 Amiens, France

INSERM Unit 1088, Jules Verne University of Picardie, 80037 Amiens, France

Bone Biology and Endocrine Division, University Hospital of Amiens, 80054 Amiens, France

Clinical Research Center, University Hospital of Amiens, 80054 Amiens, France

Department of Clinical Nephrology, University Hospital of Amiens, 80054 Amiens, France

Received 28 May 2014; Revised 18 July 2014; Accepted 14 August 2014; Published 27 August 2014

Academic Editor: Andreas Tomaschitz

Copyright © 2014 Farshad Kajbaf et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Aim. To examine the relationship between plasma 25-hydroxyvitamin D 25OHD levels and blood hemoglobin A1c HbA1c levels in diabetic patients at various stages of chronic kidney disease CKD. Methods. We screened for data collected between 2003 and 2012. The correlation between 25OHD and HbA1c levels was studied in patients categorized according to the severity of CKD and their vitamin D status. A multivariate linear regression model was used to determine whether 25OHD and HbA1c levels were independently associated after adjustment for a number of covariates including erythrocyte metformin levels. Results. We identified 542 reports from 245 patients. The mean HbA1c value was % in vitamin D sufficiency, % in insufficiency, and % in deficiency . There was a negative correlation between 25OHD and HbA1c levels for the population as a whole , and in the CKD severity subgroups , and , for CKD stages 1–3 and 4-5, resp

In the multivariate analysis, the 25OHD level was the only factor associated with HbA1c . Conclusion. 25OHD levels were negatively correlated with HbA1c levels independently of study covariates.





Autor: Farshad Kajbaf, Romuald Mentaverri, Momar Diouf, Albert Fournier, Said Kamel, and Jean-Daniel Lalau

Fuente: https://www.hindawi.com/



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