Does Comorbidity Increase the Risk of Dengue Hemorrhagic Fever and Dengue Shock SyndromeReport as inadecuate

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ISRN Tropical MedicineVolume 2013 2013, Article ID 139273, 5 pages

Research Article

Department of Community Medicine, Gujranwala Medical College, Gujranwala, Pakistan

Fatima Jinnah Medical College, Lahore, Pakistan

Department of Infectious Diseases, Shaukat Khanum Memorial Hospital, Lahore, Pakistan

Received 18 June 2013; Accepted 24 July 2013

Academic Editors: P. A. Nogueira and M. A. Sosa

Copyright © 2013 Shahid Mahmood et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Background. Dengue fever is an emerging public health problem in Pakistan. The aim of this study was to determine the relationship between comorbid conditions in individuals suffering from dengue fever and the development of dengue hemorrhagic fever or dengue shock syndrome. Methods. In this age- and sex-matched case control study, total of 132 cases of dengue hemorrhagic fever-dengue shock syndrome and 249 randomly selected controls were recruited from two major teaching hospitals of Lahore, Pakistan. A semistructured questionnaire was used to collect data through interview and by reviewing clinical records. SPSS version 18 was utilized for statistical analysis including conditional logistic regression. Results. Odds of developing dengue hemorrhagic fever DHF and dengue shock syndrome DSS among diabetics are higher than in controls, but this association was not found statistically significant OR. 1.26; 95% CI. 0.78–2.03; . Similarly, no association was observed in individuals suffering from hypertension OR. 0.93; 95% CI. 0.57–1.49; . Odds of developing DHF and DSS were higher for bronchial asthma adjusted OR. 1.34 and pulmonary tuberculosis adjusted OR. 1.41; however P values were insignificant. Conclusion. Presence of diabetes mellitus, hypertension, ischemic heart disease and bronchial asthma among patients contracted dengue fever will not increase the risk of dengue hemorrhagic fever and dengue shock syndrome.

Author: Shahid Mahmood, Saadia Hafeez, Hiba Nabeel, Urooj Zahra, and Hammad Nazeer



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