Fever Burden Is an Independent Predictor for Prognosis of Traumatic Brain InjuryReportar como inadecuado




Fever Burden Is an Independent Predictor for Prognosis of Traumatic Brain Injury - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Objective

To evaluate fever burden as an independent predictor for prognosis of traumatic brain injury TBI.

Methods

This retrospective study involved 355 TBI patients with Glasgow Coma Scale GCS ≤14, who presented at the emergency department of our hospital between November 2010 and October 2012. At 6 months follow-up, patients were divided into 5 groups based on Glasgow Outcome Scale GOS and dichotomized to GOS score high 4 to 5 vs. low 1 to 3. The relationship between fever burden and GOS was assessed.

Results

Fever burden increased as GOS scores decreased from 5 to 2, except for score 1 of GOS, which corresponded to a significant lower fever burden. Following dichotomization, patients in the high GOS group were younger, and showed less abnormal pupil reactivity P<0.001, a higher median GCS score P<0.001, and a lower median fever burden P<0.001, compared with patients in the low GOS group. Univariate logistic regression analysis revealed that poor TBI prognosis was related to age, GCS, pupil reactivity, and fever burden OR: 1.166 95% CI: 1.117–1.217 P<0.0001. Multivariate logistic regression analysis identified fever burden as an independent predictor of poor prognosis after TBI OR 1.098; 95% CI: 1.031–1.169; P = 0.003. These observations were confirmed by evaluation of the receiver operating characteristic ROC curve for fever burden area under the curve AUC 0.73 95% CI: 0.663–0.760.

Conclusion

Fever burden might be an independent predictor for prognosis of TBI. High fever burden in the early stage of the disease course associated with TBI could increase the risk of poor prognosis.



Autor: Long Bao , Du Chen , Li Ding, Weihua Ling, Feng Xu

Fuente: http://plos.srce.hr/



DESCARGAR PDF




Documentos relacionados