CMV Latent Infection Improves CD8 T Response to SEB Due to Expansion of Polyfunctional CD57 Cells in Young IndividualsReportar como inadecuado




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Cytomegalovirus CMV latent infection has a deleterious effect on the efficacy of influenza vaccination in the elderly, suggesting that CMV restricts immunological diversity impairing the immune system functionality in old age. Polyfunctional T cells produce multiple cytokines and higher amounts than mono-functional T cells. High number of polyfunctional T cells correlates with better prognosis during infection. Thus, the efficiency of T cell response associates with quality polyfunctionality rather than with quantity percentage of T cells. We analyze the effect of CMV infection on CD8+ T cells polyfunctionality ―degranulation CD107a, IFN-gamma and TNF-alpha production―, from young CMV-seropositive and CMV-seronegative individuals and in middle age CMV-seropositive donors, in response to Staphylococcal Enterotoxin B SEB. Our results show a higher percentage of polyfunctional CD8+ T cells in young CMV-seropositive individuals compared to CMV-seronegative. Also, we find an expansion of CD8+CD57+ T cells in CMV-seropositive individuals, which are more polyfunctional than CD8+CD57− cells. In middle age individuals there is a higher frequency of SEB-responding CD8+ T cells, mainly TNF-alpha or TNF-alpha-IFN-gamma producers, whereas the percentage of polyfunctional cells IFN-gamma-TNF-alpha-CD107a is similar to the percentages found in young CMV-seropositive. Therefore, whereas it has been shown that CMV latent infection can be detrimental for immune response in old individuals, our results indicate that CMV-seropositivity is associated to higher levels of polyfunctional CD8+ T cells in young and middle age donors. This increase in polyfunctionality, which can provide an immunological advantage in the response to other pathogens, is due to a CD8+CD57+ T cell expansion in CMV-seropositive individuals and it is independent of age. Conversely, age could contribute to the inflammation found in old individuals by increasing the percentage of cells producing pro-inflammatory cytokines. These findings highlight the necessity of further studies on the benefits-detrimental effects of CMV infection in the response to vaccination and other infections.



Autor: Alejandra Pera , Carmen Campos, Alonso Corona, Beatriz Sanchez-Correa, Raquel Tarazona, Anis Larbi, Rafael Solana

Fuente: http://plos.srce.hr/



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