Report of Recombinant Norovirus GII.g-GII.12 in Beijing, ChinaReportar como inadecuado




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Background

Norovirus NoV has been recognized as the most important cause of nonbacterial acute gastroenteritis affecting all age group people in the world. Genetic recombination is a common occurance in RNA viruses and many recombinant NoV strains have been described since it was first reported in 1997. However, the knowledge of recombinant NoV in China is extremely limited.

Methods

A total of 685 stool specimens were tested for NoV infection from the acute gastroenteritis patients who visited one general hospital in Beijing from April 2009 to November 2011. The virus recombination was identified by constructing phylogenetic trees of two genes, further SimPlot and the maximum chi-square analysis.

Results

The overall positive rate was 9.6% 66-685. GII.4 New Orleans 2009 and GII.4 2006b variants were the dominant genotype. Four GII.g-GII.12 and one GII.12-GII.3 recombinant strains were confirmed, and all derived from adult outpatients. The predictive recombination point occurred at the open reading frame ORF1-ORF2 overlap.

Conclusions

The GII.g ORF1-GII.12ORF2 recombinant has been reported in several countries and it was the first report of this recombinant in China.



Autor: Shaowei Sang, Zhongtang Zhao, Jijiang Suo, Yubin Xing, Ning Jia, Yan Gao, Lijun Xie, Mingmei Du, Bowei Liu, Shiwang Ren, Yunxi Li

Fuente: http://plos.srce.hr/



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