Quantitative T2 Magnetic Resonance Imaging Compared to Morphological Grading of the Early Cervical Intervertebral Disc Degeneration: An Evaluation Approach in Asymptomatic Young AdultsReportar como inadecuado




Quantitative T2 Magnetic Resonance Imaging Compared to Morphological Grading of the Early Cervical Intervertebral Disc Degeneration: An Evaluation Approach in Asymptomatic Young Adults - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Objective

The objective of this study was to evaluate the efficacy of quantitative T2 magnetic resonance imaging MRI for quantifying early cervical intervertebral disc IVD degeneration in asymptomatic young adults by correlating the T2 value with Pfirrmann grade, sex, and anatomic level.

Methods

Seventy asymptomatic young subjects 34 men and 36 women; mean age, 22.80±2.11 yr; range, 18–25 years underwent 3.0-T MRI to obtain morphological data one T1-fast spin echo FSE and three-plane T2-FSE, used to assign a Pfirrmann grade I–V and for T2 mapping multi-echo spin echo. T2 values in the nucleus pulposus NP, n = 350 and anulus fibrosus AF, n = 700 were obtained. Differences in T2 values between sexes and anatomic level were evaluated, and linear correlation analysis of T2 values versus degenerative grade was conducted.

Findings

Cervical IVDs of healthy young adults were commonly determined to be at Pfirrmann grades I and II. T2 values of NPs were significantly higher than those of AF at all anatomic levels P<0.000. The NP, anterior AF and posterior AF values did not differ significantly between genders at the same anatomic level P>0.05. T2 values decreased linearly with degenerative grade. Linear correlation analysis revealed a strong negative association between the Pfirrmann grade and the T2 values of the NP P = 0.000 but not the T2 values of the AF P = 0.854. However, non-degenerated discs Pfirrmann grades I and II showed a wide range of T2 relaxation time. T2 values according to disc degeneration level classification were as follows: grade I >62.03 ms, grade II 54.60–62.03 ms, grade III <54.60 ms.

Conclusions

T2 quantitation provides a more sensitive and robust approach for detecting and characterizing the early stage of cervical IVD degeneration and to create a reliable quantitative in healthy young adults.



Autor: Chun Chen , Minghua Huang , Zhihua Han, Lixin Shao, Yan Xie, Jianhong Wu, Yan Zhang, Hongkui Xin, Aijun Ren, Yong Guo, Deli Wang,

Fuente: http://plos.srce.hr/



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