Association of Matrix Metalloproteinase-3 -11715A>6A Polymorphism with Cancer Risk: A Meta-Analysis of 41 StudiesReportar como inadecuado




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Background and Objective

Evidence has shown that matrix metalloproteinases-3 MMP3 is important for cancer progression. Recent studies about the association between the -11715A>6A polymorphism in MMP3 promoter region and cancer risk have yielded conflicting results.

Methodology-Principal Findings

We performed a meta-analysis of 41 studies including 11112 cases and 11091 controls to determine whether the -11715A>6A polymorphism of MMP3 was associated with cancer risk. We assessed the strength of association and performed sub-group analyses by cancer types, ethnicity, smoking status, genotyping method, source of controls and sample size. The pooled results revealed that no significant association of the -11715A>6A polymorphism with overall cancer risk in any of four models. Further sub-group analysis revealed that individuals with the 6A allele had lower risk of gastrointestinal cancer in two models: heterozygote comparison 6A-5A vs. 5A-5A: OR = 0.74, 95%CI: 0.60—0.91; I2 = 1.9%, and dominant model 6A-6A+6A-5A vs. 5A-5A: OR = 0.77, 95%CI: 0.64—0.94; I2 = 29.0%. Additionally, the associations were significant in Asian populations for three models: homozygote comparison 6A-6A vs. 5A-5A, OR = 0.68, 95%CI: 0.52—0.90; I2 = 26.7%, heterozygote comparison 6A-5A vs. 5A-5A: OR = 0.75, 95%CI: 0.58—0.98; I2 = 0.0%, and dominant model 6A-6A+6A-5A vs. 5A-5A: OR = 0.69, 95%CI: 0.54—0.88; I2 = 0.5%. It was noteworthy that we had a contrary finding in non-smokers: the variant 6A-6A homozygote might statistically increase cancer risk compared with 6A-5A+5A-5A genotype OR = 1.92, 95%CI: 1.25—2.96; I2 = 72.7%.

Conclusion

This meta-analysis suggests that the -11715A>6A polymorphism in MMP3 promoter region is not associated with overall cancer risk, but it may contribute to decreased cancer risk in Asian population when compared with Caucasian population and significantly reduce the risk of gastrointestinal cancer.



Autor: Xin Yang, Jing-Wen Hu, Man-Tang Qiu, Ming Li, Rong Yin, Jie Wang, Lin Xu , Qin Zhang

Fuente: http://plos.srce.hr/



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