Increasing Newly Diagnosed Rate and Changing Risk Factors of HCV in Yanbian Prefecture, a High Endemic Area in ChinaReportar como inadecuado




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Background

The newly diagnosed rate of HCV infection is increasing in China. However, the risk factors have not been fully identified. Here, a survey was performed in Yanbian Prefecture, a high-endemic area in China.

Methods

We identified newly diagnosed HCV infection in 2007–2011, using the local National Disease Supervision Information Management System from the Chinese Center for Disease Control and Prevention. We determined the risk factors using a case-control survey by questionnaire.

Results

Yanbian Prefecture had a rapid increase in the yearly newly diagnosed rate of HCV infection from 32.6 to 72.1-100.000 from the year 2007 to 2011. People aged 50–64 years had a high HCV infection of 43.4%, but only 0.3% of cases were reported in those aged less than 20 years. Cosmetic treatment, family history, blood transfusion, and dental treatment were independent risk factors for HCV infection. Unexpectedly, cosmetic treatments odd ratio OR = 5.15, 95% confidence interval CI = 2.31–11.48, P = 0.00 and family history OR = 4.68, 95% CI = 2.67–8.75, P = 0.00 showed a higher risk than the conventional risk factors of blood transfusion OR = 4.49, 95% CI = 1.95–10.37, P = 0.001 and dental treatment OR = 2.98, 95% CI = 1.42–6.25, P = 0.00. To further analyze the intrafamilial transmission, we found that spouses of HCV patients had an increased risk for acquiring HCV OR = 5.75, 95% CI: 1.94–17.07, without significant association between either HCV RNA viral load P = 0.29 or genotype P = 0.43.

Conclusions

HCV infection was increased in Yanbian Prefecture. Cosmetic treatment was a higher risk factor than medical procedure. HCV infection had a clear family clustering phenomenon, especially between spouses.



Autor: Hong-Xin Piao , Ai-Ting Yang , Ya-Meng Sun, Yuan-Yuan Kong, Xiao-Ning Wu, Ying-Zhe Zhang, Bo Ding, Bao-En Wang, Ji-Dong Jia, Hong

Fuente: http://plos.srce.hr/



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