BRAFV600E Mutation Analysis in Patients with Metastatic Colorectal Cancer mCRC in Daily Clinical Practice: Correlations with Clinical Characteristics, and Its Impact on Patients’ OutcomeReportar como inadecuado




BRAFV600E Mutation Analysis in Patients with Metastatic Colorectal Cancer mCRC in Daily Clinical Practice: Correlations with Clinical Characteristics, and Its Impact on Patients’ Outcome - Descarga este documento en PDF. Documentación en PDF para descargar gratis. Disponible también para leer online.

Background

To prospectively evaluate the usefulness of the BRAFV600E mutation detection in daily clinical practice in patients with metastatic Colorectal Cancer mCRC.

Patients and Methods

504 mCRC patients treated with systemic chemotherapy ± biologics were analyzed.

Results

A statistically significant higher incidence of the BRAF mutation was observed in patients with ECOG-PS 2 p=0.001, multiple metastatic sites p=0.002,> 65 years old p=0.004, primary tumors located in the colon p<0.001, high-grade tumors p=0.001 and in those with mucinous features p=0.037. Patients with BRAFV600E mutated tumors had a statistically significantly reduced progression-free survival PFS compared to wild-type wt ones 4.1 and 11.6 months, respectively; p<0.001 and overall survival OS 14.0 vs. 34.6 months, respectively; p<0.001. In the multivariate analysis the BRAFV600E mutation emerged as an independent factor associated with reduced PFS HR: 4.1, 95% CI 2.7–6.2; p<0.001 and OS HR: 5.9, 95% CI 3.7–9.5; p<0.001. Among the 273 patients treated with salvage cetuximab or panitumumab, the BRAFV600E mutation was correlated with reduced PFS 2.2 vs. 6.0 months; p<0.0001 and OS 4.3 vs. 17.4 months; p<0.0001.

Conclusions

The presence of BRAFV600E-mutation in mCRC characterizes a subgroup of patients with distinct biologic, clinical and pathological features and is associated with very poor patients’ prognosis.



Autor: Zacharenia Saridaki, Maria Tzardi, Maria Sfakianaki, Chara Papadaki, Alexandra Voutsina, Aristea Kalykaki, Ippokratis Messaritaki

Fuente: http://plos.srce.hr/



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