Incident Chronic Kidney Disease and Newly Developed Complications Related to Renal Dysfunction in an Elderly Population during 5 Years: A Community-Based Elderly Population Cohort StudyReport as inadecuate




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Background

Few studies have evaluated the association between incident chronic kidney disease CKD and related complications, especially in elderly population. We attempted to verify the association between GFR and concurrent CKD complications and elucidate the temporal relationship between incident CKD and new CKD complications in a community-based prospective elderly cohort.

Method

We analyzed the available data from 984 participants in the Korean Longitudinal Study on Health and Aging. Participants were categorized into 6 groups according to eGFR at baseline examination ≥90, 75–89, 60–74, 45–59, 30–44, and <30 ml-min-1.73 m2.

Result

The mean age of study population was 76 ± 9.1 years and mean eGFR was 72.3 ± 17.0 ml-min-1.73 m2. Compared to eGFR group 1, the odds ratio OR for hypertension was 2.363 95% CI, 1.299-4.298 in group 4, 5.191 2.074-12.995 in group 5, and 13.675 1.611-115.806 in group 6; for anemia, 7.842 2.265-27.153 in group 5 and 13.019 2.920-58.047 in group 6; for acidosis, 69.580 6.770-715.147 in group 6; and for hyperkalemia, 19.177 1.798-204.474 in group 6. Over a 5-year observational period, CKD developed in 34 9.6% among 354 participants with GFR ≥ 60 ml-min-1.73 m2 at basal examination. The estimated mean number of new complications according to analysis of co-variance was 0.52 95% CI, 0.35–0.68 in subjects with incident CKD and 0.24 0.19–0.29 in subjects without CKD p = 0.002. Subjects with incident CKD had a 2.792-fold higher risk of developing new CKD complications. A GFR level of 52.4 ml-min-1.73 m2 p = 0.032 predicted the development of a new CKD complication with a 90% sensitivity.

Conclusion

In an elderly prospective cohort, CKD diagnosed by current criteria is related to an increase in the number of concurrent CKD complications and the development of new CKD complications.



Author: Shin Young Ahn, Jiwon Ryu, Seon Ha Baek, Sejoong Kim, Ki Young Na, Ki Woong Kim, Dong-Wan Chae, Ho Jun Chin

Source: http://plos.srce.hr/



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