Investigating the Association of ApoE Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of DementiaReport as inadecuate




Investigating the Association of ApoE Genotypes with Blood-Brain Barrier Dysfunction Measured by Cerebrospinal Fluid-Serum Albumin Ratio in a Cohort of Patients with Different Types of Dementia - Download this document for free, or read online. Document in PDF available to download.

Background

Since more than a decade ApoE is known to be a strong risk factor for Alzheimer-s disease AD; however, molecular pathways mediating this risk are still unclear. In recent years it has been hypothesized that ApoE might play a role in the disintegration of blood-brain barrier BBB. In the present study we addressed the question if ApoE genotypes might be associated with BBB function measured by albumin ratio QAlb in a large cohort of patients with different types of dementia.

Methods

Five hundred twenty 520 patients with Creutzfeldt-Jakob disease CJD, n = 350, Alzheimer-s disease n = 71 and cerebral small vessel disease n = 99 were assessed for their ApoE genotype. BBB function was measured in all patients using QAlb and was compared between ApoE genotypes. Dominant and additive genetic models were assumed in order to investigate the potential effect of ApoE on BBB function.

Results

We observed no systematic differences in QAlb between ApoE genotypes within the present study. Increased QAlb levels were shown for those without E3 allele in the subgroup of CJD patients when assuming a dominant genetic model p = 0.035. This could not be confirmed for patients with other forms of dementia p = 0.234.

Discussion

Although there was some evidence for a protective effect of E3 alleles in CJD patients, this study does not support the hypothesis of a systematic role of ApoE genotypes in BBB function in individuals with a diagnosis of dementia. Thus, changes in BBB function do not seem to contribute to the increased risk of cognitive decline associated with certain ApoE genotypes. The interpretation of the results of this study must take into account that BBB function was only assessed by measuring QAlb which has been shown to be a good marker for overall BBB integrity but might not reflect all qualities of the barrier.



Author: André Karch , Henrike Manthey, Claudia Ponto, Peter Hermann, Uta Heinemann, Christian Schmidt, Inga Zerr

Source: http://plos.srce.hr/



DOWNLOAD PDF




Related documents