Optic Radiations Microstructural Changes in Glaucoma and Association With Severity: A Study Using 3Tesla-Magnetic Resonance Diffusion Tensor ImagingReport as inadecuate




Optic Radiations Microstructural Changes in Glaucoma and Association With Severity: A Study Using 3Tesla-Magnetic Resonance Diffusion Tensor Imaging - Download this document for free, or read online. Document in PDF available to download.

1 UB - Université de Bordeaux 2 CHU de Bordeaux Pellegrin Bordeaux 3 LaBRI - Laboratoire Bordelais de Recherche en Informatique 4 Service de neurologie Bordeaux 5 Epidémiologie et Biostatistique Bordeaux

Abstract : Purpose:To compare microstructural changes along the optical radiations and brain structure volumes between glaucoma and control subjects using in vivo magnetic resonance imaging and to analyze their association with severity of the disease. Methods: 50 open-angle glaucoma subjects and 50 healthy age- and sex-matched controls underwent detailed ophthalmological examinations including visual field testing VF, funduscopy and Spectral-Domain Optical Coherence Tomography as well as Diffusion tensor imaging DTI using a 3.0-Tesla MRI. Fractional anisotropy FA, Mean Diffusivity, Radial Diffusivity RD and Axial Diffusivity AD were quantified semi-automatically along the optical radiations. DTI parameters and volumes of specific brain structures were compared between cases and controls using conditional logistic regression. Association between DTI metrics and the severity of the disease was studied using linear mixed regression analyses.Results: In glaucoma subjects, optic radiations FA was significantly lower 0.57 vs 0.59; p= 0.02 and RD was significantly higher 52.78 10-5 mm2-s vs 49.74 10-5 mm2-s; p= 0.03 than in controls. Optic radiations FA was significantly correlated with homolateral functional and structural damage of glaucoma mean deviation of VF p=0.03, retinal nerve fiber layer thickness p=0.03, vertical cup-disc ratio p=0.0007. Volume and DTI parameters of other brain structures including hippocampus were not significantly different between glaucoma and controls. Conclusion: We evidenced microstructural modifications along visual pathways of glaucoma patients and these alterations were correlated with disease severity. The association of glaucoma with other neurodegenerative alterations would need further exploration and a prospective follow-up of our cohort of subjects.





Author: Laury Tellouck - Muriel Durieux - Pierrick Coupé - Audrey Cougnard-Grégoire - Joy Tellouck - Thomas Tourdias - Fanny Munsch - A

Source: https://hal.archives-ouvertes.fr/



DOWNLOAD PDF




Related documents